Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

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Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

Peptide mimics of intracellular loop 2 (ic2) of the human 5HT1a receptor have been studied with respect to their ability to inhibit agonist binding via interference with receptor-G-protein coupling. These peptides give shallow concentration-effect relationships. Additionally, these peptides have been studied with respect to their ability to trigger the signal transduction system of this Gi-coup...

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ژورنال

عنوان ژورنال: International Journal of Peptides

سال: 2012

ISSN: 1687-9767,1687-9775

DOI: 10.1155/2012/490734